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Chunk #23 — Discussion — CHRNA5-A3-B4 and smoking abstinence

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Association of CHRNA5-A3-B4 SNP rs2036527 with smoking cessation therapy response in African-American smokers.
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Lastly, our findings suggested that roughly 60% of African Americans (i.e. individuals with rs2036527[G/G] genotype) would benefit greatly from active smoking cessation treatments, whereas the 40% with the rs2036527[A] variant may not. This demonstrates the potential value of pharmacogenetic approaches in improving smoking cessation outcomes among African American smokers (30, 31).