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Chunk #12 — MATERIALS and METHODS — Genotyping and Quality Control

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Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population.
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For Sample 2 (MEGA), the study is ongoing; 589 Thai subjects have been phenotyped to date; 536 of these were genotyped by MEGA array. One subject was removed due to mismatched genotype and phenotypic sex; one subject was removed due to low genotype call rate (< 0.95); four subjects were removed because they were duplicates. Five hundred and thirty subjects remained for analysis. Only autosomal SNPs were retained; SNPs with low genotype call rate (< 0.95) MAF < 0.01 or HWE P < 10−6 were removed. 728,129 SNPs remained for imputation.