Of the variants showing strong association with BMI, only rs9939609 (in FTO) showed nominally significant evidence of heterogeneity across cohorts (P = 0.02, Supplementary Table 5), and none of the associations showed significantly different effects by sex (P > 0.16, Supplementary Table 5). We did not observe any significant evidence supporting the recently reported BMI associations with SNPs near INSIG2 (rs7566605, P = 0.98) and CTNNBL1 (rs6013029, P = 0.34)13,14. We did observe modest evidence for association between BMI and variation in PCSK1 (rs6232, P = 0.03 in the appropriate direction), which has previously been associated with severe obesity11.
