Chunk #32 — Online Methods — Stratified LD score regression

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Partitioning heritability by functional annotation using genome-wide association summary statistics.

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yes

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We assume a linear model: yi=∑jXijβj+εi where yi is a quantitative phenotype in individual i, Xij is the standardized genotype of individual i at the j-th SNP, βj is the effect size of SNP j, and εi is mean-zero noise. We define heritability by