SZ hiPSC NPCs revealed reproducible SZ-associated phenotypes; future studies must now demonstrate they relate to disease etiology. SZ hiPSC NPCs may serve as a proxy for the developmental pathways potentially contributing to SZ pathogenesis, much as Huntington's disease hiPSC NPCs have been shown to recapitulate elements of Huntington's disease pathogenesis.32 In vitro assays for neural migration and oxidative stress are scalable and amenable to high-throughput screening. This approach is suitable for large cohorts of SZ patients, making it a potentially valuable tool in the study of this complex and heterogeneous disorder.
