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Chunk #6 — Tight regulation of epoxygenated fatty acids (EFAs) — EFA production

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Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception.
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diversity. However the large number of biological processes that the EFAs mediate support the idea that different EFAs have non-overlapping functions [19–22]. With the exception of the epoxides of LA, the plasma and cellular levels of free EFAs are typically in the low single digit nM range suggesting that these molecules function at exceedingly low concentrations.