scan panel as used in this analysis. Analysis of a combined trait of BMI, drug dependence and / or regular tobacco use in the same sample reached a MLS of 4.1 at 151 cM on chr6q25.2. A search of the Sullivan Lab Evidence Project psychiatric genetics database (47) for genome wide linkage and association findings in the 2 LOD support interval flanking our MLS annotates findings with bipolar, schizophrenia, major depressive disorder, ADHD, and autism disorders (Supplementary Table 2). Psychiatric disorders are well-known to be comorbid with cigarette smoking; it has been estimated that the majority of cigarettes smoked in the United States are smoked by individuals fulfilling standardized criteria for nicotine dependence and a diagnosis of a psychiatric disorder (48).
