Table 1uses the Kinship Coefficient generated from KING to tabulate the observed pairwise relationship status based upon genome-wide data versus the expected pairwise relationships based upon information from Add Health (using the Add Health variable, “sibcl4”). The sibcl4 variable is one of the classification variables available for the Add Health sibling pairs subsample. This particular classification designates pairs of respondents into monozygotic twin pair (MZ), dizygotic twin pair (DZ), full sibling pair (FS), half-sibling pair (HS), cousin pair (CO), unrelated pair (UN) and undetermined relationship (UD). A total of 1,781,328 (1888C2) pairwise relationship comparisons were conducted. As recommended by the authors of KING (Manichaikul et al., 2010), a Kinship Coefficient greater than 0.354 is categorized as an MZ twin pair (duplicates have been removed), between 0.177 and 0.354 as 1st degree relationship (DZ twin pairsand full sibling pairs - no parent-offspring are present), between 0.0884 and 0.177 as 2nd degree relationship (half-sibling pair and avuncular), between 0.0442 and 0.0884 as 3rd degree relationship (half-avuncular and first cousin) and less than 0.0442 as not related (NR).Note that the expected values for
