Further evidence for a role of resting-state increased connectivity in some circuits as a core neural activity associated with psychotic symptoms comes from a recent fMRI pharmacological study demonstrating that antipsychotic-induced reduction of baseline functional hyperconnectivity in drug-naïve first episode schizophrenia correlated with clinical recovery of the patients [69]. Altogether, these findings suggest that a pattern of hyperconnectivity between certain brain regions may be an indicator of a vulnerability to psychosis and an early abnormality in both schizophrenia and the schizophrenia-like disorder occurring in epilepsy. It is noteworthy that although most studies looking at functional connectivity in psychoses [3]–[5], [20], [22], [70] and in epilepsy syndromes [71], [72] have used fMRI, the few existing EEG data on brain connectivity during rest in schizophrenia indicate that psychosis-related abnormal functional connectivity between cortical areas often occur in faster oscillations, particularly in the beta frequency band [73]. This supports our findings of altered beta2-phase synchronization in patients with SLPE.
