represent specializations shared across vessel types. For example, IC 10 loads onto cells with both artery and vein markers and strongly contributing genes suggest a signal related to host immunity, including genes encoding interferons (Ifit3, Ifit1, Ifit2, and Ifitm3), GTPases induced by interferons (Iigp1, Irgm1, and Gbp7), and other proteins involved in the anti-viral response (Isg15 and Rsad2) (Figure 2E). These examples identify endothelial processes within (e.g. arterial angiogenesis) or across (e.g. host defense) vessel types. Other signals might reflect cell states specialized for iron handling, calcium signaling, and the stress response (Data S4G).
