In conclusion, our data provide a first step towards identification of GIPR variants potentially involved in obesity. Most likely variations in the putative regulatory region of the gene (e.g. rs2302382) are the most promising candidates for independent validations in case-control samples or in selected family samples as well as ultimately in functional studies. If our findings indeed are truly positive, this study also supports the observation [26,49] that cross-sectional population-based studies seem to be less powerful to detect obesity-marker associations as they are rarely enriched with extremely obese individuals.
