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Chunk #0 — Introduction

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A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.
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560,000 cases of upper aerodigestive tract (UADT) cancers (encompassing of the oral cavity, pharynx, larynx and esophagus) are estimated to occur each year world-wide [1]. Exposure to alcohol and tobacco [1] are the major UADT cancer risk factors in Europe and the Americas, with infection with human papillomavirus also playing an important role [2].