function (Celentano et al. 1988; Reynolds and Prasad 1991; Aguayo 1990; Nishio and Narahashi 1990; Sapp and Yeh 1998), but this sort of effect has not been observed in every neuronal type examined (e.g. McCool et al. 2003; White et al. 1990; Yamashita et al. 2006). A tonic GABAA-mediated current is observed in many CNS neurons, and is thought to reflect the function of extrasynaptic, high affinity GABA receptors containing the δ receptor subunit (Hanchar et al. 2005). The Potentiation of this tonic current has been observed in recordings from cerebellum, hippocampus, and thalamus using the brain slice preparation (Hanchar et al. 2005; Wei et al. 2004; Glykys et al. 2007; Jia et al. 2008, although see Botta et al. 2007).
