Table 3 illustrates the association results in detail. In the combined analysis, the strongest signal came from the association of a synonymous SNP (rs1044394) with ND; the minor allele “A” at this locus was associated with a lower risk of ND (P = 0.001, OR = 0.73, 95% CI = 0.61–0.89). Subgroup analysis demonstrated a similar pattern of association in AAs (P = 0.009, OR = 0.74, 95% CI = 0.60–0.93) and EAs (P = 0.05, OR = 0.66, 95% CI = 0.43–1.00). Rs1044394 was also significantly associated with FTND (P = 0.01), and showed non-significant evidence for association with CPD (P = 0.083) in the combined samples. Another SNP (rs2236196), which has a low correlation with rs1044394 (r2 = 0.26 and 0.22 for AAs and EAs, respectively), was significantly associated with CPD (P = 0.003) in the combined sample, as well as in AAs (P = 0.022) and EAs (P = 0.049) separately. Note that the coefficient for rs2236196 is opposite in sign for CPD in AAs and EAs; this is attributable to the fact that the minor allele
