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Chunk #33 — Results — Dlx1/2-/- Constitutive and Zfhx1b Conditional Mutants Have Similar Changes in Gene Expression Related to Their Defects in Interneuron Migration

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Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons.
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Lhx6+ cells are lacking throughout the cortex and increased in the striatum of both the Dlx1/2-/- and Zfhx1b mutants (Figures 6D-F”). Likewise, Sst+ and NPY+ cortical interneurons were lost, whereas their expression was increased in the striatum (Figures 6J-L”; Sst data not shown).