We have developed ConsensusPathDB, a database for integrating human molecular interaction networks, in order to address such a comprehensive integration of interaction data. The integrated content comprises different types of functional interactions that interconnect diverse types of cellular entities. In order to gain an immediate critical number of interactions, we have focused primarily on the integration of existing database resources although our schema has also been used for additional manual upload of experimental interactions. Currently, the database contains human functional interactions, including gene regulations, physical (protein–protein and protein-compound) interactions and biochemical (signaling and metabolic) reactions, obtained by integrating such data from 12 publicly accessible databases (referred to as source databases): Reactome (12), KEGG (13) (metabolic reactions only), HumanCyc (14), PID (http://pid.nci.nih.gov), BioCarta (http://www.biocarta.com), NetPath (http://www.netpath.org), IntAct (15) (data from small-scale experiments only), DIP (16), MINT (17), HPRD (18), BioGRID (19) and SPIKE (20). In this article, we describe the methods used for data integration, the database schema, as well as the main functions of the web interface.
