Samples used in this study are summarized in Table 1. In all target datasets, about 60% of cases were males while <42% of controls were males.Table 1Sample summary.PopulationTarget dataset# case (%male)# control (%male)# total# familiesAAAlla2786 (60.80)3529 (39.27)63153322COGA875 (62.06)2500 (41.60)3375590SAGE387 (59.17)543 (37.02)930869YalePenn1524 (60.50)486 (29.84)20101863EAIndiana Biobank539 (62.15)3515 (40.40)40544054aCOGA, SAGE, and YalePenn combined.