SCZ GWAS are greater than sample sizes for BiP and MDD. In addition, an important limitation of the current study is that only EA individuals were included due to the majority EA composition of these discovery GWAS, as cross-ancestry predictions have the potential to yield biased (or confounded) estimates68. Future directions of this work include cross-ancestry replication of these effects using new results from the Genomic Psychiatry Cohort (GPC)69 and joint analyses of other SCZ cohorts with available clinical data, especially as related to age at onset and specific SCZ symptom clusters. Findings from this study of unaffected individuals from the general population (i.e., in the absence of clinical features of SCZ or a family history of SCZ) should be compared with patterns observed in clinical samples of those with SCZ, BiP, and MDD. In addition, EEG studies could be paired with fMRI to combine the advantages of the superior spatial resolution of MRI and the superior temporal resolution of EEG, to better understand findings from both modes of measuring functional connectivity.
