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Chunk #7 — Methods — Study sample and setting

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Comparison of DSM-IV and DSM-5 criteria for alcohol use disorders in VA primary care patients with frequent heavy drinking enrolled in a trial.
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The CHOICE trial was conducted at three VA primary care clinics (Seattle, Tacoma, and Mount Vernon, Washington). Patients were considered potentially eligible if they were 21–75 years old and had a positive alcohol screen documented at the time of a VA outpatient visit (Alcohol Use Disorders Identification Test Consumption questionnaire [AUDIT-C] score ≥4 points for women and ≥5 for men). These cut-offs were chosen to maximize the positive predictive value for AUD. [15] In addition, providers could refer patients and flyers were posted so patients could self-refer to the study. Potentially eligible and referred patients were contacted by telephone and determined to be eligible if they reported drinking at levels that exceeded National Institute on Alcohol Abuse and Alcoholism (NIAAA) daily drinking limits on a phone screen—4 drinks (women) or 5 drinks (men), hereafter “binge”—at least twice a week on average, or once a week on average if they also reported they had ever been in alcohol treatment or attended Alcoholics Anonymous [16]. This was used as a proxy screen for AUD for the CHOICE trial because, due to stigma