Chunk #20 — Methods — Collaborative Study on the Genetics of Alcoholism (COGA) data

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The quantitative trait linkage disequilibrium test: a more powerful alternative to the quantitative transmission disequilibrium test for use in the absence of population stratification.

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The data are from families participating in the Collaborative Study on the Genetics of Alcoholism (COGA) [7]. We restricted our analyses to non-Hispanic Whites to minimize population stratification. The dataset consists of 1,074 individuals in 119 pedigrees. All statistical genetic analyses were conducted using maximum likelihood-based variance decomposition approaches implemented in SOLAR.