Although the number of single-base substitutions was significantly higher in Aldh2−/−Fancd2−/− genomes (Fig. 5b), the total numbers were low and no changes were detected in the type of substitutions (Fig. 5c). We also found no difference in the frequency or pattern of point mutations in bone marrow cells of Aldh2−/−Fancd2−/− mice using the Select-cII Big Blue in vivo reporter assay (Extended Data Fig. 5).
