Considering smoking behaviors, CYP2A6 rs113288603 also showed a nominal association with smoking status (current vs. former smokers): carriers of the rs113288603 * T (protective for hearing loss) allele are less likely to be current smokers than non-carriers (p = 0.047). We also observed another nominal association between the CYP2A6 * V110L (rs72549435) and years of smoking: carriers of CYP2A6 * L110 allele smoke more years than non-carriers (p = 0.015). No other associations were observed between CYP2A6 alleles and smoking behaviors (Supplemental Table 3).
