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Chunk #11 — Results — Analytic power and accuracy

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Power and predictive accuracy of polygenic risk scores.
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The expressions for power and accuracy are derived in terms of the parameters listed in Table 1. Estimates of marker effects are either obtained from linear regression or set to a signed constant, which corresponds to the common approach of counting risk alleles across markers. A proportion of markers is assumed to have no effect, and markers may be selected by thresholding on their P-values.