To gain insights into the brain chromatin, we compared the adult PsychENCODE Hi-C dataset with those from other tissues in a similar fashion to the transcriptomic and epigenomic comparisons described above. In particular, we selected a set of tissues and cell types from ENCODE and Roadmap, consistently processed their associated Hi-C data at a low resolution, and compared them with our reference-brain Hi-C data. As expected, we found that all the samples for adult brain regions tend to separate markedly from the other tissues in terms of A-B compartment similarity and other metrics (Fig. 5D and fig. S38).
