its performance to closely mirror the two-sample two-stage least squares (TS2SLS) method,37 a variant of TSLS that can be applied to individual participant data in the two-sample setting, given their asymptotic equivalence. The simulations are repeated in the Web Appendix (available as Supplementary data at IJE online) in a one-sample setting. In this case, we found that the performance of standard one-sample TSLS and the IVW method were indeed highly similar.