The mediating role of primary major depression on the childhood maltreatment–AAD association was investigated using multiple logistic regression. The influence of measured family-level variables (parental psychopathology, parenting, and parental demographic variables) on the childhood maltreatment–AAD association was investigated by structural modeling analyses of the phenotypic data. Family-level confounding was evaluated based on the change in the maltreatment–AAD correlation estimate in a baseline correlational model versus a partial mediation model that regressed AAD and maltreatment on each family variable. Standard errors and statistical tests were adjusted to account for correlated observations by allowing twins within pairs to be correlated (but the correlations across twins and among predictors were otherwise unstructured).
