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Chunk #43 — RESULTS — APPLICATION TO REAL DATA — TESTING ASSOCIATIONS

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Case-control association testing in the presence of unknown relationships.
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After correction of relatedness among individuals, the p-values increased, which implies less significant associations between disease and markers. The ten markers with the smallest p-values are reported in Table V for the Guam study and Table VI for the Kosrae study. For the Guam study, the correction for cryptic relatedness gave a p-value that was 1-3 orders of magnitude higher than that from the uncorrected test, while for the Kosrae study, the p-values for all these extreme markers increased by one order of magnitude.