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Chunk #22 — 3. Results — 3.2. Effects of ethanol on gene expression in the ACB

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Gene expression changes in the nucleus accumbens of alcohol-preferring rats following chronic ethanol consumption.
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(d) ‘regulation of kinase activity’ with a total of 11 gene expression differences, with 7 higher (Cdc42, Dusp6, Pkib, Spdy1, Spry2, Tgfa) and 4 lower (Cav, Dgka, Plce1, Rgs3) in the CA group; (e) ‘negative regulation of protein kinase activity’ with a total of 5 gene expression differences, 3 higher (Dusp6, Pkib, Spry2) and 2 lower (Cav, Rgs3) in the CA group; (f) ‘regulation of MAPK activity’ with a total of 7 gene expression differences, 4 higher (Chrna7, Dusp6, Spry2, Tgfa) and 3 lower (cav, Plce1, Rgs3) in the CA group; (g) ‘regulation of G-protein coupled receptor protein signaling pathway’ with a total of 6 genes displaying decreased expression levels (Ece1, Plce1, Rasgrp4, Ramp2, Rgs3, Rgs9) in the CA group; and (h) ‘anatomical structure formation’ with a total of 11 gene expression differences, 7 higher (Btg1, Ctgf, Nr4a3, Pofut1, Scg2, Scye1, Tgfa) and 4 lower (Angptl4, Tek, Hdh, Tie1) in the CA group.