volunteers (N = 96) who had received placebo or d-amphetamine (10, 20 mg) in a double-blind, within-subjects laboratory-based study. A SNP in CSNK1E (rs135745) was associated with the subjectively euphoric effects of amphetamine (Veenstra-VanderWeele et al. 2006), providing some support for the proposed relationship between the locomotor response to stimulant drugs and the subjectively pleasurable effects of drugs in humans and providing a promising link between the animal and human genetic models. This study focuses on Stage 2 in Table 1 and is based on the idea that acute locomotor response in mice is related to subjectively positive drug effects in humans.
