To compare the genetic signal between specific PGC2 subsets, LDSC12 was used to estimate heritability and genetic correlations. Small EUA studies with N < 200 cases and total effective sample size of N < 500 were selected (N = 24 studies; GWAS including 2102 cases and 7366 controls, effective N = 5162) and compared to larger studies. To reduce standard error given this relatively small sample, we estimated heritability with the LDSC intercept constrained to 1, after first testing that the intercept was not significantly different from 1.
