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Chunk #16 — Discussion

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Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel.
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We expect that many other studies may be able to make use of our approach to produce highly accurate haplotypes in their samples. It is likely that many cohorts that undergo sequencing will already have SNP microarray genotypes available. For example, twin studies that have sequenced one individual from each dizygotic twin pair, and also have genotype data on all individuals, may benefit substantially from using our approach. The phasing of the twins genotype data will be highly accurate in regions of shared haplotypes, and this will help in genotype calling and phasing of the sequence data. Studies which have sequenced one individual from parent-child pairs will benefit in a similar manner. The final version of the 1000GP haplotypes on all of the ~2,500 samples will be phased using our new approach.