of intoxication at age 17 and AD symptoms at age 22) with genetic risk specific to alcohol use behaviors in later adolescence into young adulthood (17-22). Importantly, within these overall trajectories, several interesting sex differences emerged, effects that are masked when examining mean levels of male and female alcohol use behavior across development. We found that the relationship between genetic risk and problematic drinking across development is moderated by the individual’s sex; AUD-GR influenced adolescent alcohol outcomes (i.e. early initiation of use, intoxication frequency) in females more than in males and by age 22, EXT-GR influenced AD criteria more for males than females. In addition, the association between genetic risk and intoxication frequency was greater among 14 and 17 year old females with male co-twins.
