Chunk #17 — Materials and methods — Replication using data from the Australian Twin-family Study of Alcohol Use Disorder (OZ-ALC)

Source

RNA alternative splicing impacts the risk for alcohol use disorder.

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This dataset, including genotypes and DSM-IV alcohol-dependence phenotypes, was downloaded from dbGaP (phs000181.v1.p1) [25]. As in COGA, we limited the replication analysis to European American (EA) individuals (n = 2856), and the pedigree matrix was constructed in the same way. Additionally, sex, age, and the first three principal components of population stratification as specified by OZ-ALC were included as covariates in the replication analysis.