The sample for this study included both probands and affected relatives. Probands met the following criteria: (1) lifetime diagnosis of AN by DSM-IV criteria excluding the amenorrhea criterion because of the unreliability of its retrospective assessment in females, and replicated data indicating that individuals with and without amenorrhea do not differ meaningfully [Gendall et al., 2006; Poyastro Pinheiro et al., 2007]; (2) low weight that is/was less than the 5th percentile of body mass index (BMI) for age and gender according to the Hebebrand et al. [1996] NHANES chart; (3) ages 13 and 65 years; (4) eating disorder onset prior to age 25; and (5) having met criteria for AN not less than 3 years prior to ascertainment. Affected relatives were defined as biological family members who were (1) between the ages of 13 and 65 years, and (2) had lifetime eating disorder diagnoses of modified DSM-IV AN (again excluding amenorrhea), lifetime eating disorder diagnoses of DSM-IV bulimia nervosa (BN)-purging type or nonpurging type, or an eating disorder not otherwise specified (EDNOS)—sub-threshold AN, sub-threshold BN, or sub-threshold mixed (relatives who
