identify have not been validated in experiments that directly manipulate neural activity. Consequently, while various techniques may identify correlated activity between two different cortical regions, a direct interaction between the two can only be confirmed by direct and focal stimulation that changes the activity of one of the regions. (3) Therapeutic interventions that modulate neural networks in a specific and targeted fashion have not been developed, as most traditional pharmaceutical measures modulate the activity of entire networks rather than by targeting specific dysfunctional nodes or connections.
