In summary, this cerebellar eGWAS study and the temporal cortex validations provide insight about the genetics of brain gene expression, a framework to guide future studies with respect to tissue/region/disease choice in eQTL studies, examples about the utility of this approach in gene mapping, replication of some known transcript associations and evidence for novel transcript associations in human disease. Combined eGWAS-disease GWAS approach may provide complementary information in mapping human disease and enable identification of functional variants that may not be possible by either approach alone.
