concomitant within-session reductions.25 It is also in line with the earlier observation that manipulations which facilitate long-term extinction in CB1R knockout mice (for example, spaced training) do not produce within-session extinction.50 On the other hand, there is evidence that nonspecific stimulation of the endocannabinoid system with the CB1 agonist WIN55212 or endocannabinoid reuptake blockade by AM404 treatment can facilitate within-session extinction in a strain of rats that, unlike S1, show intact trait extinction.51 The reasons for the absence of AM3056′s effects on extinction learning remain to be determined, but likely relate to either the specificity of the drug's actions on anandamide or the extinction-resistant model used, or a combination of the two.
