by different characteristics of the genome, such as chromosome, minor allele frequency, and functional annotation, a method of attaching relevant biological information to genomic elements. (See J. J. Lee, Vattikuti, & Chow, 2016, for a discussion.) GREML also can be used to derive estimates of the genetic correlation between traits (S. H. Lee, Yang, Goddard, Visscher, & Wray, 2012), as can cross-trait LD Score regression (Bulik-Sullivan et al., 2015), thus permitting endophenotype researchers to address criterion #4 in Table 1 using measured variants.
