Chunk #72 — 5. Procedures for evaluating pharmacological treatments targeting alcohol abuse and dependence — 5.9. Summary

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Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.

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P rats and 4 with AA rats), and (c) relapse to ethanol-drinking behavior were examined in 9 studies (all of these conducted with P rats). In general, the vast majority of studies were conducted on the maintenance of ethanol drinking or self-administration and in male rats. Thus, more research is needed on possible sex-differences as well as ethanol-seeking and relapse-like drinking (also see Section 8. Future directions).