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Chunk #6 — Materials and methods — Data Analysis — Phenotype modeling

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Genome-Wide Meta-Analysis of Longitudinal Alcohol Consumption Across Youth and Early Adulthood.
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derived from the best fitting longitudinal model of the several tested, and maximized power through including all repeated measures, while (2) the mean consumption outcome provided a simpler summary of individuals’ drinking behavior, and thus greater continuity to existing literature (Agrawal et al., 2012; Grant et al., 2009). The mean consumption measure also has the benefit of focusing solely on adolescence and the transition to adulthood—a developmental period of non-normative drinking, which is associated with increased risk of concurrent comorbid psychiatric disorders and future substance abuse and dependence (Rutter et al., 1999).