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Chunk #25 — Results — Candidate gene association analysis — CRH-BP — Haplotype analyses

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Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP.
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In the Plains Indians there were four haplotypes that accounted for 97% of the haplotype diversity (Table 6). An ANOVA revealed no global significant association between haplotypes and alpha power (F(2,589) = 2.4, p = 0.095). The two yin-yang haplotypes, 22122 and 11211, were associated with the lowest and highest alpha power respectively: p = 0.035). Haplotype frequencies differed in individuals with and without anxiety disorders: anxiety vs non anxiety: 11111: 0.12 vs 0.08; 11211: 0.23 vs 0.14; 22122: 0.65 vs 0.78 (χ2 = 6.4, 2df, p = 0.041).