strongest association was for rs8020095 (p=1.05 × 10-7), located in the gene GPHN. When the discovery and replication samples were combined into one meta-analysis of 22 studies with 51,258 respondents, one region (indexed by the SNP rs40465) was associated with depressive symptoms at genome-wide levels of significance.56 This variant is in a “gene desert,” an area of the genome where there are long regions without protein-coding sequences and unknown biological function.
