Chunk #41 — Online Methods — Variant detection

Source

Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples.

Embedded

yes

Text

L[Mfm]=P({bi}∣{ei},r,m,f)=∏i=1dP(bi∣ei,r,m,f) assuming the sequencing errors are independent across reads. If all substitution errors are equally likely, i.e. occur with probability ei/3, we obtain