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Chunk #37 — Methods — Model fitting

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Integrating functional data to prioritize causal variants in statistical fine-mapping studies.
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yes

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Despite the fact that posterior probabilities are calculated independently at each locus, we can set up the objective function to aggregate the results and borrow information across loci to compute estimates of . In doing so, we prevent over fitting of the data to any one locus, offering more robust estimates of the model parameters leading, in turn, to more accurate posterior probabilities. We define our Q function for the M step as follows