Data Fig. 6), reflecting that pluripotency was maintained during culture. In principle, the estimated donor variation could arise due to shared reprogramming environment because lines were derived from the same population of fibroblast cells. However, expression quantitative trait locus (eQTL) effect sizes mapped using Tier 1 expression data (Supplementary Table 4, Extended Data Fig. 6) revealed that higher donor variation was associated with larger effect sizes of lead eQTL variants (Fig. 3e), suggesting that donor variance primarily reflects genetic differences.
