Interestingly, the TAS-low drugs were enriched in antimicrobial agents that would not be expected to target human proteins (Figure 5B). An exception to this was the antimicrobial triclosan, which yielded a high TAS score, consistent with its having effects in mammalian cells. The safety of triclosan has recently been questioned (Dinwiddie et al., 2014; Yueh et al., 2014).
