Further, in a hypothetical world where genotypic information is used to make decisions about prevention intervention, what do we do about the kids that are deemed “less likely to respond”? Fortunately, many studies thus far suggest that those who are most at risk are actually most likely to respond to intervention (Albert et al., 2015; Bakermans-Kranenburg & van Ijzendoorn, 2011; Brody et al., 2013). If personalized prediction is used to make choices between different programs, the issue of how to handle “likely unresponsive” children becomes less problematic. But we need to be careful about the possibility of classifying kids in ways that could result in labeling and/or potential for discrimination or self-fulfilling prophecies. If a group of kids are identified for whom prevention is less effective, it will be an important area of study to determine how better to support these children.