We previously showed that the interaction between childhood trauma and FKBP5 variation influenced suicide attempts in this sample of African Americans (Roy et al., 2010). Since the effectiveness of CRH in stimulating ACTH with resultant cortisol release is governed in part by CRHBP and since the effectiveness of cortisol in influencing gene expression via the GR is moderated by a molecular complex that includes FKBP5, we further hypothesized that there would be an additive effect between CRHBP and FKBP5 variation in the interaction with childhood trauma to predict risk for suicide attempt.
