The total population and all sub-populations (Manchester and Budapest samples, and subjects with or without lifetime depression, respectively) were in Hardy-Weinberg equilibrium (p>0.05). The genotype frequency was not significantly different in the Budapest and Manchester samples (pADD = 0.154) which allowed us to carry out mega-analyses in the combined sample. Description of the population can be seen in Table 1. Increase of either RLE or CHA exposure positively correlated with BSI depression and anxiety scores, and caused sharp increase in risk of lifetime depression (Supporting Information and Fig. A in S1 File).
