Chunk #3 — Endocannabinoid Variants and Childhood Adversity Predict Cannabis Dependence Symptoms and Amygdala Habituation — Challenges with A Priori Selection of Candidate Variants
the implementation of early genetic association studies to a limited number of handpicked variants across genes and/or gene-tagging single nucleotide polymorphisms (SNPs). However, recent improvements in feasibility, customizability, and affordability of genome-wide arrays, the practicality of imputing, and the efficiency of data analysis (particularly with software packages such as PLINK; Purcell et al., 2007; Chang et al., 2015) have rendered some custom candidate gene panels obsolete. The availability of high density arrays with superior gene coverage allow for the study of candidate gene systems, an approach more amenable to hypothesis-testing.
